According to photos and videos seen by kenyagist.com, billows of smoke could be seen invading the sky from more than a kilometre away.
The smoke filled the air as residents tried to put out the flames before the emergency services arrived.
At the time of publishing, the cause of the inferno was yet to be established.
The fire reportedly destroyed property valued to be worth millions of shillings.
Stores used by the traders to house their trading material were completely destroyed in the inferno
This comes just months after another huge fire razed down Gikomba Market, Nairobi.
First responders rushed to the scene to help put out the inferno and prevent it from spreading to the nearby areas.
Fires which have burned down various markets in Nairobi often point to powerful individuals who seek to forcefully evict traders.
In August, Marikiti traders were left counting losses after a fire destroyed part of the market in Nairobiâ€™s Central Business District (CBD).
According to the traders, there was a land dispute prior to the inferno.
The government has been building modern markets to house traders across the county.